Article
Mammalian mutation pressure, synonymous codon choice, and mRNA degradation.
Journal of molecular evolution - 1 Dec 2003
Duan Jubao, Antezana Marcos A
Abstract excerpt
The usage of synonymous codons (SCs) in mammalian genes is highly correlated with local base composition and is therefore thought to be determined by mutation pressure. The usage is nonetheless structured. For instance, mammals share with Saccharomyces and Drosophila most preferences for the C-ending over the G-ending codon (or vice versa) within each fourfold-degenerate SC family and the fact that their SCs are...
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