Article

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genes

2026-08-24

Abstract excerpt

Oncogenes and tumor-suppressor genes play opposing roles in cancer biology to promote and restrict growth, respectively. Codon usage patterns interface with tRNA modifications to control translation, leading to gene-specific codon signatures with regulatory potential. As such, codon-biased translational regulation has been identified as a driver of proliferation and drug resistance in multiple cancers. We used adv...

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Literature Corpus work: 787737a4-2395-57d8-98de-d4b8b3c14ee8
DOI: 10.64898/2026.08.21.746283

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