Article

Synonymous codon usage regulates translation initiation

2022-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Synonymous codon usage regulates gene expression such that transcripts rich in optimal codons produce significantly more protein than their nonoptimal counterparts. A major unresolved issue has been understanding the mechanisms by which synonymous codons regulate gene expression. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger mRN...

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Literature Corpus work: 5fca394b-1c9e-54b3-b790-b695be621427
DOI: 10.1101/2022.05.13.491887

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