Article

Third-nucleotide codon bias and synonymous codon bias define functional translational programs that shape human tissue and cancer proteomes

2025-11-03

Abstract excerpt

<h4>Background</h4> Codon usage bias is a universal feature of the genetic code, yet how synonymous codon bias or third-nucleotide codon bias (A/T-vs G/C-ending) shape translation and proteome composition across tissues and cancer remain unclear. <h4>Results</h4> Using comparative genomics between human and rodent coding sequences, we uncovered a conserved codon-bias axis. A/T-ending codons consistently marked g...

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Literature Corpus work: d995f8a9-c484-560b-a339-7239d2b9b5ec
DOI: 10.1101/2025.10.31.685942

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