Article
Vertebrate codon bias indicates a highly GC-rich ancestral genome.
Gene - 25 Apr 2013
Nabiyouni Maryam, Prakash Ashwin, Fedorov Alexei
Abstract excerpt
Two factors are thought to have contributed to the origin of codon usage bias in eukaryotes: 1) genome-wide mutational forces that shape overall GC-content and create context-dependent nucleotide bias, and 2) positive selection for codons that maximize efficient and accurate translation. Particularly in vertebrates, these two explanations contradict each other and cloud the origin of codon bias in the taxon. On...
Topics
- Animals
- Base Composition
- Chickens
- Codon
- Computational Biology
- Databases, Genetic
- Evolution, Molecular
- Gene Expression
- Genome
- Humans
- Mutation
- Nucleotides