Prevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers.

doi:10.1371/journal.pone.0160463

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Article

Prevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers.

PloS one - 1 Jan 2016

Wu Xudong, Li Guohui

Abstract excerpt

Cancer is characterized by uncontrolled cell growth, and the cause of different cancers is generally attributed to checkpoint dysregulation of cell proliferation and apoptosis. Recent studies have shown that non-optimal codons were preferentially adopted by genes to generate cell cycle-dependent oscillations in protein levels. This raises the intriguing question of how dynamic changes of codon usage modulate the...

Topics

Amino Acids
Codon
Evolution, Molecular
Genomics
Humans
Models, Genetic
Mutation
Neoplasms
Prevalence
Selection, Genetic

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PMID: 27513638
DOI: 10.1371/journal.pone.0160463
PMCID: PMC4981346

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