Article

Codon usage and amino acid identity are major determinants of mRNA stability in humans

2018-12-07

Abstract excerpt

mRNA degradation is a critical, yet poorly understood, aspect of gene expression. Previous studies demonstrate that codon content acts as a major determinant of mRNA stability in model organisms. In humans, the importance of open reading frame (ORF)-mediated regulation remains unclear. Here, we globally analyzed mRNA stability for both endogenous and human ORFeome collection mRNAs in human cells. Consistent with p...

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Identifiers and source

Literature Corpus work: 58f81498-38b1-5653-97cb-4d7a54743137
DOI: 10.1101/488676

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