Article

Codon bias coevolves with longevity

2025-12-19

Abstract excerpt

<h4>Summary</h4> Somatic mutations drive carcinogenesis and aging, shortening the lifespan of animals. Since the vulnerability of genes strongly depends on their size and the abundance of mutation hotspots, we have tested whether negative selection of hypermutable (e.g., CpG bearing) codons could play a role in the evolution of longevity in mammals. Our studies have shown that the CGA codon was significantly more...

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Literature Corpus work: b4182140-1247-5e44-a5a3-1deae7b124ad
DOI: 10.64898/2025.12.17.694825

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