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Article

Somatic mutation driven codon transition bias in human cancer.

Scientific reports - 27 Oct 2017

Son Hyeonju, Kang Hyundeok, Kim Hyun Seok, Kim Sangwoo

Abstract excerpt

Accumulation of DNA mutations alters amino acid sequence in the key domains of oncoproteins, leading to cellular malignant transformation. Due to redundancy of the genetic code, the same amino acid alteration can be achieved by multiple distinct genetic mutations, which are considered functionally identical and not actively distinguished in the current cancer genome research. For the first time, we analyzed the...

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PMID: 29079855
DOI: 10.1038/s41598-017-14543-1
PMCID: PMC5660177

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