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Article

Natural Selection Shapes Codon Usage in the Human Genome.

American journal of human genetics - 2 Jul 2020

Dhindsa Ryan S, Copeland Brett R, Mustoe Anthony M, Goldstein David B

Abstract excerpt

Synonymous codon usage has been identified as a determinant of translational efficiency and mRNA stability in model organisms and human cell lines. However, whether natural selection shapes human codon content to optimize translation efficiency is unclear. Furthermore, aside from those that affect splicing, synonymous mutations are typically ignored as potential contributors to disease. Using genetic sequencing...

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Identifiers

PMID: 32516569
DOI: 10.1016/j.ajhg.2020.05.011
PMCID: PMC7332603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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