Article

Human POLD3 coordinates leading and lagging strand in Mitotic DNA Synthesis

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Deregulation of origin firing and licensing, shortage of deoxyribonucleotides in the cell and interference between transcription and replication are among the causes of DNA replication stress in cancer cells. This leads in various ways (notably, through common fragile sites expression and incomplete replication of late-replicating genomic regions during S phase) to the necessity of finishing DNA...

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Literature Corpus work: dba1bfa1-9c71-5d61-8036-b6ec235958ca
DOI: 10.64898/2025.12.15.694317

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