Article

Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements

2018-09-26

Abstract excerpt

<h4>SUMMARY</h4> DNA replication errors generate complex chromosomal rearrangements and thereby contribute to tumorigenesis and other human diseases. Although the events that trigger these errors are not well understood, one candidate is mitotic entry before the completion of DNA replication. To address the impact of mitosis on DNA replication, we employed Xenopus egg extracts. When mitotic CDK (Cyclin B1-CDK1)...

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Literature Corpus work: 7f1e9b18-837c-5c0a-8541-1288b51345ab
DOI: 10.1101/428433

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