Article

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cells

2020-08-19

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication is well orchestrated in mammalian cells through a tight regulation of the temporal order of replication origin activation, named the replication timing, a robust and conserved process in each cell type. Upon low replication stress, the slowing of replication forks induces delayed replication of fragile regions leading to genetic instability. The impact of low replication stress o...

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Literature Corpus work: 3b65de90-e4ad-5553-8dff-b3a084ff4327
DOI: 10.1101/2020.08.19.256883

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