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Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells

23 May 2013

Abstract excerpt

Treslin/TICRR (TopBP1-interacting, replication stimulating protein/TopBP1-interacting, checkpoint, and replication regulator), the human ortholog of the yeast Sld3 protein, is an essential DNA replication factor that is regulated by cyclin-dependent kinases and the DNA damage checkpoint. We identified MDM two binding protein (MTBP) as a factor that interacts with Treslin/TICRR throughout the cell cycle. We show...

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PMID: 23704573
DOI: 10.1126/science.1237448

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