Article

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair

2019-12-18

Abstract excerpt

<h4>ABSTRACT</h4> DNA polymerase delta (Pol δ ) plays several essential roles in eukaryotic DNA replication and repair. At the replication fork, Pol δ is responsible for the synthesis and processing of the lagging-strand. At replication origins, Pol δ has been proposed to initiate leading-strand synthesis by extending the first Okazaki fragment. Destabilizing mutations in human Pol δ subunits cause replicatio...

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Literature Corpus work: 45b9c26c-c231-5611-a1b4-837bb00098c5
DOI: 10.1101/2019.12.17.879544

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