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Article

Tracking break-induced replication shows that it stalls at roadblocks.

Nature - 1 Feb 2021

Liu Liping, Yan Zhenxin, Osia Beth A, Twarowski Jerzy, Sun Luyang, Kramara Juraj, Lee Rosemary S, Kumar Sandeep, Elango Rajula, Li Hanzeng, Dang Weiwei, Ira Grzegorz, Malkova Anna

Abstract excerpt

Break-induced replication (BIR) repairs one-ended double-strand breaks in DNA similar to those formed by replication collapse or telomere erosion, and it has been implicated in the initiation of genome instability in cancer and other human diseases1,2. Previous studies have defined the enzymes that are required for BIR1-5; however, understanding of initial and extended BIR synthesis, and of how the migrating...

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Identifiers

PMID: 33473214
DOI: 10.1038/s41586-020-03172-w
PMCID: PMC8219245

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