Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road.

Genes - 29 Jan 2023

Barnes Ryan P, Thosar Sanjana A, Opresko Patricia L

Abstract excerpt

Telomeres present inherent difficulties to the DNA replication machinery due to their repetitive sequence content, formation of non-B DNA secondary structures, and the presence of the nucleo-protein t-loop. Especially in cancer cells, telomeres are hot spots for replication stress, which can result in a visible phenotype in metaphase cells termed "telomere fragility". A mechanism cells employ to mitigate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA Replication
Share to Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 36833275
DOI: 10.3390/genes14020348
PMCID: PMC9956152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road.PMID 36833275Read ↗

Pathways for maintenance of telomeres and common fragile sites during DNA replication stressSemantic proximity Read ↗

Challenging endings: How telomeres prevent fragilitySemantic proximity Read ↗

Rescue from replication stress during mitosisSemantic proximity Read ↗

DNA replication stress: Causes, resolution and diseaseSemantic proximity Read ↗

Unravelling the Intricacies of Telomere Replication: A Molecular ConundrumSemantic proximity Read ↗

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanismSemantic proximity Read ↗

Bring It to an End: Does Telomeres Size Matter?Semantic proximity Read ↗

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication ProcessesSemantic proximity Read ↗

Portrait of replication stress viewed from telomeres.Semantic proximity Read ↗

Telomere dysfunction and genome instabilitySemantic proximity Read ↗

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.Semantic proximity Read ↗

R-loop and diseases: the cell cycle matters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.