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Dynamics of human replication factors in the elongation phase of DNA replication

11 Oct 2007

Abstract excerpt

In eukaryotic cells, DNA replication is carried out by coordinated actions of many proteins, including DNA polymerase delta (pol delta), replication factor C (RFC), proliferating cell nuclear antigen (PCNA) and replication protein A. Here we describe dynamic properties of these proteins in the elongation step on a single-stranded M13 template, providing evidence that pol delta has a distributive nature over the 7...

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PMID: 17932049
DOI: 10.1093/nar/gkm822

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