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Article

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.

Cellular and molecular life sciences : CMLS - 1 Jul 2017

Giannattasio Michele, Branzei Dana

Abstract excerpt

DNA replication stress, an important source of genomic instability, arises upon different types of DNA replication perturbations, including those that stall replication fork progression. Inhibitors of the cellular pool of deoxynucleotide triphosphates (dNTPs) slow down DNA synthesis throughout the genome. Following depletion of dNTPs, the highly conserved replication checkpoint kinase pathway, also known as the...

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Identifiers

PMID: 28220209
DOI: 10.1007/s00018-017-2474-4
PMCID: PMC5487892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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