Back to search

Article

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

2025-09-10

Abstract excerpt

<h4>SUMMARY</h4> DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segregation in favor of alternative pathways that depend on TOPBP1 and CIP2A, but how they function is still poorly defined. Here, we describe the identification of DDIAS as a mitosis-specific DNA damage...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8676616d-4544-541a-9f2f-fa7f6187b157
DOI
10.1101/2025.09.09.675193
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisDOI 10.1101/2025.09.09.675193
TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity
CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity
Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity
Mitotic tethering enables <i>en masse</i> inheritance of a shattered micronuclear chromosomeSemantic proximity
Mitotic chromatin marking governs asymmetric segregation of DNA damageSemantic proximity
On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity
Whole genome doubling confers unique genetic vulnerabilities on tumor cellsSemantic proximity
BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repairSemantic proximity
CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiencySemantic proximity
Potential Cancer Biomarkers: Mitotic Intra-S DNA Damage Checkpoint GenesSemantic proximity
A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage responseSemantic proximity
Select a neighboring publication to make it the new centre.