Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of human POLD1 and POLD3 in genome stability

15 Dec 2016

Abstract excerpt

DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of genome instability, frequently associated with cancer and aging. POLD1 is the catalytic subunit and POLD3 is an accessory subunit of the replicative Pol δ polymerase, which also functions in DNA repair, as well as the translesion synthesis polymerase Pol ζ, whose catalytic subunit is REV3L. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27974823
DOI: 10.1038/srep38873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of human POLD1 and POLD3 in genome stabilityPMID 27974823Read ↗

Human POLD3 coordinates leading and lagging strand in Mitotic DNA SynthesisSemantic proximity Read ↗

POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies.Semantic proximity Read ↗

Roles of POL3, POL2 and PMS1 genes in maintaining accurate DNA replication.Semantic proximity Read ↗

POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development.Semantic proximity Read ↗

Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates.Semantic proximity Read ↗

REV1 and polymerase ζ facilitate homologous recombination repairSemantic proximity Read ↗

Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.Semantic proximity Read ↗

Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repairSemantic proximity Read ↗

Regulation of human DNA polymerase delta in the cellular responses to DNA damageSemantic proximity Read ↗

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.Semantic proximity Read ↗

A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M.Semantic proximity Read ↗

The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.