Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.

doi:10.1101/gr.195248.115

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.

Genome research - 1 Mar 2016

Sheu Yi-Jun, Kinney Justin B, Stillman Bruce

Abstract excerpt

Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins in a temporally specific manner during S phase. The replicative helicase Mcm2-7 functions in both initiation and fork progression and thus is an important target of regulation. Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control from multiple kinase signaling pathways, including the...

Topics

Alkylating Agents
Alleles
Cell Cycle Proteins
Checkpoint Kinase 2
Chromosomes, Fungal
Cyclin-Dependent Kinases
DNA Replication
DNA-Binding Proteins
Hydroxyurea
Minichromosome Maintenance Complex Component 4
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphorylation

Replication Origin

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Deletion

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 26733669
DOI: 10.1101/gr.195248.115
PMCID: PMC4772014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.PMID 26733669Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signalingSemantic proximity Read ↗

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Semantic proximity Read ↗

CDC7 and CDK8 kinases cooperate to support DNA replication origin firing in human cellsSemantic proximity Read ↗

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.Semantic proximity Read ↗

Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.Semantic proximity Read ↗

A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Semantic proximity Read ↗

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinksSemantic proximity Read ↗

Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human CellsSemantic proximity Read ↗

A p53-dependent FBXO44-RAD18 axis limits mutagenesis by terminating translesion DNA synthesisSemantic proximity Read ↗

Regulation and roles of Cdc7 kinase under replication stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.