Article

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

2019-01-03

Abstract excerpt

To initiate X-chromosome inactivation (XCI), the long non-coding RNA Xist mediates chromosome-wide gene silencing of one X chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing, however is highly variable across genes, with some genes even escaping XCI in somatic cells. A genes susceptibility to Xist-mediated silencing appears to be determined by a complex interpl...

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Literature Corpus work: db626f4c-f8c7-582f-a651-f4a06abee6f2
DOI: 10.1101/510198

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