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Article

Advances in understanding chromosome silencing by the long non-coding RNA Xist.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jan 2013

Sado Takashi, Brockdorff Neil

Abstract excerpt

In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX females and XY males. X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied for half a century. In the last two decades, efforts have been focused on the X inactive-specific transcript (Xist) locus,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23166390
DOI: 10.1098/rstb.2011.0325
PMCID: PMC3539355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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