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Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation

29 Jun 2021

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BACKGROUND: X-chromosome inactivation (XCI) is the epigenetic inactivation of one of two X chromosomes in XX eutherian mammals. The inactive X chromosome is the result of multiple silencing pathways that act in concert to deposit chromatin changes, including DNA methylation and histone modifications. Yet over 15% of genes escape or variably escape from inactivation and continue to be expressed from the otherwise...

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PMID: 34187555
DOI: 10.1186/s13072-021-00404-9

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