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Article

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Genome biology - 3 Aug 2015

Marks Hendrik, Kerstens Hindrik H D, Barakat Tahsin Stefan, Splinter Erik, Dirks René A M, van Mierlo Guido, Joshi Onkar, Wang Shuang-Yin, Babak Tomas, Albers Cornelis A, Kalkan Tüzer, Smith Austin, Jouneau Alice, de Laat Wouter, Gribnau Joost, Stunnenberg Hendrik G

Abstract excerpt

BACKGROUND: During early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated to compensate for a potential imbalance in transcript levels with male cells, which contain a single X chromosome. Here, we use mouse female embryonic stem cells (ESCs) with non-random X chromosome inactivation (XCI) and polymorphic X chromosomes to study the dynamics of gene silencing over the...

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Identifiers

PMID: 26235224
DOI: 10.1186/s13059-015-0698-x
PMCID: PMC4546214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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