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Article

YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing.

EMBO reports - 1 May 2024

Bowness Joseph S, Almeida Mafalda, Nesterova Tatyana B, Brockdorff Neil

Abstract excerpt

X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis to silence genes on a single X chromosome in XX female cells, thereby equalising levels of X-linked gene expression relative to XY males. XCI progresses over a period of several days, with some X-linked genes silencing faster than others. The chromosomal location of a gene is an important determinant of silencing rate, but...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mouse Embryonic Stem Cells

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Source

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Identifiers

PMID: 38654121
DOI: 10.1038/s44319-024-00136-3
PMCID: PMC11094009

Genes

YY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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