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Article

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution.

Nature communications - 15 Jun 2021

Pacini Guido, Dunkel Ilona, Mages Norbert, Mutzel Verena, Timmermann Bernd, Marsico Annalisa, Schulz Edda G

Abstract excerpt

To ensure dosage compensation between the sexes, one randomly chosen X chromosome is silenced in each female cell in the process of X-chromosome inactivation (XCI). XCI is initiated during early development through upregulation of the long non-coding RNA Xist, which mediates chromosome-wide gene silencing. Cell differentiation, Xist upregulation and gene silencing are thought to be coupled at multiple levels to...

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Share to Dosage Compensation, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mouse Embryonic Stem Cells

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Source

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Identifiers

PMID: 34131144
DOI: 10.1038/s41467-021-23643-6
PMCID: PMC8206119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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