Article
Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.
The Journal of infectious diseases - 4 Jan 2018
Makvandi-Nejad Shokouh, Laurenson-Schafer Henry, Wang LiLi, Wellington Dannielle, Zhao Yan, Jin Boquan, Qin Ling, Kite Kerry, Moghadam Hooman K, Song Chaojun, Clark Kevin, Hublitz Philip, Townsend Alain R, Wu Hao, McMichael Andrew J, Zhang YongHong, Dong Tao
Abstract excerpt
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on...
Read the complete abstract on PubMed