Article
IFITM3 restricts the morbidity and mortality associated with influenza.
Nature - 25 Mar 2012
Everitt Aaron R, Clare Simon, Pertel Thomas, John Sinu P, Wash Rachael S, Smith Sarah E, Chin Christopher R, Feeley Eric M, Sims Jennifer S, Adams David J, Wise Helen M, Kane Leanne, Goulding David, Digard Paul, Anttila Verneri, Baillie J Kenneth, Walsh Tim S, Hume David A, Palotie Aarno, Xue Yali, Colonna Vincenza, Tyler-Smith Chris, Dunning Jake, Gordon Stephen B, Smyth Rosalind L, Openshaw Peter J, Dougan Gordon, Brass Abraham L, Kellam Paul
Abstract excerpt
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses. Both the magnitude and breadth...
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