IFITM3 variants point to a critical role in emergent virus infections.

doi:10.1128/mbio.03347-24

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Article

IFITM3 variants point to a critical role in emergent virus infections.

mBio - 14 May 2025

Denz Parker J, Yount Jacob S

Abstract excerpt

Interferon-induced transmembrane protein 3 (IFITM3) is a cellular protein that restricts numerous viral infections by blocking virus-host membrane fusion. In humans, there are two IFITM3 single nucleotide polymorphisms (SNPs), rs12252-C and rs34481144-A, that decrease IFITM3 activity and have been associated with severe illness following influenza virus infections. Mice lacking IFITM3 show increased influenza...

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Identifiers

PMID: 40237465
DOI: 10.1128/mbio.03347-24
PMCID: PMC12077130

Genes

IFITM3

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IFITM3 variants point to a critical role in emergent virus infections.PMID 40237465Read ↗

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IFITM3 affects the level of antibody response after influenza vaccination.Semantic proximity Read ↗

IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.Semantic proximity Read ↗

Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and PathogenesisSemantic proximity Read ↗

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