Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

IFITM3 variants point to a critical role in emergent virus infections.

mBio - 14 May 2025

Denz Parker J, Yount Jacob S

Abstract excerpt

Interferon-induced transmembrane protein 3 (IFITM3) is a cellular protein that restricts numerous viral infections by blocking virus-host membrane fusion. In humans, there are two IFITM3 single nucleotide polymorphisms (SNPs), rs12252-C and rs34481144-A, that decrease IFITM3 activity and have been associated with severe illness following influenza virus infections. Mice lacking IFITM3 show increased influenza...

Topics

Humans
RNA-Binding Proteins
Polymorphism, Single Nucleotide
Animals
Membrane Proteins
Mice
Influenza, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

SARS-CoV-2

COVID-19

Virus Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 40237465
DOI: 10.1128/mbio.03347-24
PMCID: PMC12077130

Genes

IFITM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFITM3 variants point to a critical role in emergent virus infections.PMID 40237465Read ↗

IFITM3 restricts the morbidity and mortality associated with influenza.Semantic proximity Read ↗

IFITM3 restricts the morbidity and mortality associated with influenzaSemantic proximity Read ↗

Antiviral Protection by IFITM3 In VivoSemantic proximity Read ↗

IFITM-Family Proteins: The Cell's First Line of Antiviral DefenseSemantic proximity Read ↗

Ifitm3 limits the severity of acute influenza in mice.Semantic proximity Read ↗

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibilitySemantic proximity Read ↗

IFITM3 affects the level of antibody response after influenza vaccination.Semantic proximity Read ↗

IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.Semantic proximity Read ↗

Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and PathogenesisSemantic proximity Read ↗

IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral InfectionsSemantic proximity Read ↗

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.Semantic proximity Read ↗

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.