Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.

Nature medicine - 1 Aug 2017

Allen E Kaitlynn, Randolph Adrienne G, Bhangale Tushar, Dogra Pranay, Ohlson Maikke, Oshansky Christine M, Zamora Anthony E, Shannon John P, Finkelstein David, Dressen Amy, DeVincenzo John, Caniza Miguela, Youngblood Ben, Rosenberger Carrie M, Thomas Paul G

Abstract excerpt

Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial. We prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5' UTR. We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to CD8-Positive T-Lymphocytes
Share to DNA Methylation
Share to Influenza, Human
Share to Interferon Regulatory Factor-3
Share to Repressor Proteins
Share to RNA-Binding Proteins
Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 28714988
DOI: 10.1038/nm.4370
PMCID: PMC5702558

Genes

IFITM3
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.PMID 28714988Read ↗

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibilitySemantic proximity Read ↗

IFITM3 variants point to a critical role in emergent virus infections.Semantic proximity Read ↗

Antiviral Protection by IFITM3 In VivoSemantic proximity Read ↗

Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.Semantic proximity Read ↗

Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infectionSemantic proximity Read ↗

IFITM3 restricts the morbidity and mortality associated with influenza.Semantic proximity Read ↗

IFITM3 Rs12252-C Variant Increases Potential Risk for Severe Influenza Virus Infection in Chinese Population.Semantic proximity Read ↗

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza.Semantic proximity Read ↗

Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity.Semantic proximity Read ↗

IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis.Semantic proximity Read ↗

The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.Semantic proximity Read ↗

IFITM3 and susceptibility to respiratory viral infections in the community.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.