Article

XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

2023-10-19

Abstract excerpt

XIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a naïve state of pluripotency to assess the function of XIST a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9309f49-4067-56fc-97e3-6f2023be6a63
DOI: 10.1101/2023.10.19.563078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

XIST dampens X chromosome activity in a SPEN-dependent manner during early human developmentDOI 10.1101/2023.10.19.563078Read

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.Semantic proximity Read

A Novel <i>XACT</i> lncRNA Transcript with Functions Transcending X-Chromosome InactivationSemantic proximity Read

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read

Mechanistic diversification of <i>XIST</i> regulatory network in mammalsSemantic proximity Read

Upregulation of the lncRNA <i>XACT</i> sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cellsSemantic proximity Read

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA HypomethylationSemantic proximity Read

X-chromosome dosage compensation dynamics in human early embryosSemantic proximity Read

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryoSemantic proximity Read

Defects in dosage compensation impact global gene regulation in the mouse trophoblast.Semantic proximity Read

Unleashing XIST from X-chromosome inactivationSemantic proximity Read

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.Semantic proximity Read