Article

X-chromosome dosage compensation dynamics in human early embryos

2020-03-09

Abstract excerpt

In mammals, female cells are obliged to inactivate one of two X chromosomes to achieve dosage parity with the single X chromosome in male cells, and it is also thought that the single active X chromosome is increased 2-fold to achieve dosage balance with two sets of autosomes (X:A ratio = 1, or Ohno’s hypothesis). However, the ontogeny of X-chromosome inactivation and augmentation of the single active X remains un...

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Literature Corpus work: 62275572-f057-570c-b65b-19ebb0a870e1
DOI: 10.1101/2020.03.08.982694

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