Article

A Novel <i>XACT</i> lncRNA Transcript with Functions Transcending X-Chromosome Inactivation

2025-01-03

Abstract excerpt

X-chromosome inactivation (XCI) is initiated during early mammalian embryogenesis by a long non-coding RNA (lncRNA) XIST , which coats one of the two X-chromosomes and facilitates epigenetic transcriptional silencing. A second, evolutionarily recent primate-specific lncRNA XACT was proposed to antagonize XIST ’s ability to induce XCI. XACT expression is restricted to pluripotent states and early embryonic stag...

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Literature Corpus work: 7ddd2c20-25c7-539d-b44d-d7f6f60008ae
DOI: 10.1101/2025.01.03.631201

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