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Upregulation of the lncRNA <i>XACT</i> sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cells

2025-10-03

Abstract excerpt

<h4>Summary</h4> Long noncoding RNAs (lncRNAs) represent a vast class of regulatory transcripts and are spatiotemporally controlled, yet only a few have been functionally implicated in human development. Here, we identify the X-linked lncRNA XACT , abundantly but transiently expressed during early human embryogenesis, as a critical regulator of pluripotency, lineage specification, and cancer-like states. In huma...

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Identifiers and source

Literature Corpus work
7e022f56-36f4-5f7d-95d7-6d1c6d523d91
DOI
10.1101/2025.10.02.679492
Open publication

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Upregulation of the lncRNA <i>XACT</i> sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cellsDOI 10.1101/2025.10.02.679492
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