Article
Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.
Scientific reports - 7 Sept 2017
Moreira de Mello Joana C, Fernandes Gustavo R, Vibranovski Maria D, Pereira Lygia V
Abstract excerpt
In female mammals, one X chromosome is transcriptionally inactivated (XCI), leading to dosage compensation between sexes, fundamental for embryo viability. A previous study using single-cell RNA-sequencing (scRNA-seq) data proposed that female human preimplantation embryos achieve dosage compensation by downregulating both Xs, a phenomenon named dampening of X expression. Using a novel pipeline on those data, we...
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