Article
Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.
Genes & development - 15 Jun 2005
Navarro Pablo, Pichard Sylvain, Ciaudo Constance, Avner Philip, Rougeulle Claire
Abstract excerpt
X-chromosome inactivation (XCI) is highly dynamic during early mouse embryogenesis and strictly depends on the Xist noncoding RNA. The regulation of Xist and its antisense partner Tsix remains however poorly understood. We provide here the first evidence of transcriptional control of Xist express...
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