Article

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA Hypomethylation

2020-05-22

Abstract excerpt

<h4>SUMMARY</h4> Female human pluripotent stem cells (hPSCs) are prone to undergoing X chromosome erosion (XCE), a progressive loss of key epigenetic features on the inactive X that initiates with repression of XIST , the long non-coding RNA required for X inactivation. As a result, previously silenced genes on the eroding X (Xe) reactivate, some of which are thought to provide selective advantages. To-date, the...

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Literature Corpus work: 739d8f1d-b6f4-551e-a4fd-c2d38f0e36fa
DOI: 10.1101/2020.05.20.100891

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