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Unleashing XIST from X-chromosome inactivation

26 Nov 2024

Abstract excerpt

Recognition that the most abundant class of genes present in the human genome are those producing long noncoding RNA (lncRNA) has hyped research on this category of transcripts. One such prototypical RNA, Xist, has particularly fueled interest. Initially characterized for its specific expression from the inactive X (Xi), recent studies have uncovered the molecular mechanisms underlying its essential role in the...

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PMID: 39603150
DOI: 10.1016/j.ceb.2024.102446

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