Article

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo

2024-11-26

Abstract excerpt

Sex chromosomes are emerging as key regulators of adult health and disease in males (XY) and females (XX), but their impact on embryo development is poorly understood. Using single-cell RNA sequencing (scRNA-seq) on wild type and aneuploid mouse embryos, we show that sex chromosomes significantly shape the preimplantation embryo transcriptional landscape. A hierarchy of effects are identified, distinctly mediated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f968f614-8897-5157-a785-093acbb17424
DOI: 10.1101/2024.11.26.625424

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryoDOI 10.1101/2024.11.26.625424Read

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesisSemantic proximity Read

Sex Differences in Early Embryogenesis: Inter‐Chromosomal Regulation Sets the Stage for Sex‐Biased Gene NetworksSemantic proximity Read

X-chromosome dosage compensation dynamics in human early embryosSemantic proximity Read

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.Semantic proximity Read

Transcriptional sexual dimorphism during preimplantation embryo development and its consequences for developmental competence and adult health and disease.Semantic proximity Read

Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologiesSemantic proximity Read

Defects in dosage compensation impact global gene regulation in the mouse trophoblast.Semantic proximity Read

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammalsSemantic proximity Read

Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineagesSemantic proximity Read

Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos.Semantic proximity Read

X-factors in human disease: impact of gene content and dosage regulation.Semantic proximity Read

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo developmentSemantic proximity Read