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Article

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.

PLoS biology - 1 Dec 2007

Lin Hong, Gupta Vibhor, Vermilyea Matthew D, Falciani Francesco, Lee Jeannie T, O'Neill Laura P, Turner Bryan M

Abstract excerpt

Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development. Embryonic stem (ES) cells derived from the ICM of female mice have two active X chromosomes, one of which is inactivated as the cells differentiate in culture,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18076287
DOI: 10.1371/journal.pbio.0050326
PMCID: PMC2121114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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