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Article

Defects in dosage compensation impact global gene regulation in the mouse trophoblast.

Development (Cambridge, England) - 1 Aug 2017

Sakata Yuka, Nagao Koji, Hoki Yuko, Sasaki Hiroyuki, Obuse Chikashi, Sado Takashi

Abstract excerpt

Xist RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in Xist RNA, the A-repeat has been shown to be essential for its silencing function in differentiating embryonic stem cells. Here, we introduced a new Xist allele into mouse that produces mutated Xist RNA lacking the A-repeat (XistCAGΔ5' ). XistCAGΔ5' RNA expressed...

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Share to Cells, Cultured
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique

Share to Gene Expression Regulation, Developmental

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Source

Identifiers

PMID: 28684628
DOI: 10.1242/dev.149138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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