Article

Genome-wide prediction of topoisomerase II <i>β</i> binding by architectural factors and chromatin accessibility

2020-03-23

Abstract excerpt

DNA topoisomerase II- β (TOP2B) is fundamental to remove topological problems linked to DNA metabolism and 3D chromatin architecture, but its cut-and-reseal catalytic mechanism can accidentally cause DNA double-strand breaks (DSBs) that can seriously compromise genome integrity. Understanding the factors that determine the genome-wide distribution of TOP2B is therefore not only essential for a complete knowledge...

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Literature Corpus work: d7eb96a0-0f35-55a4-bae4-37c7fac89cad
DOI: 10.1101/2020.03.23.003277

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