Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

4 Feb 2016

Abstract excerpt

Topoisomerase 1, an enzyme that relieves superhelical tension, is implicated in transcription-associated mutagenesis and genome instability-associated with neurodegenerative diseases as well as activation-induced cytidine deaminase. From proteomic analysis of TOP1-associated proteins, we identify SMARCA4, an ATP-dependent chromatin remodeller; FACT, a histone chaperone; and H3K4me3, a transcriptionally active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Mechanisms of cancer metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26842758
DOI: 10.1038/ncomms10549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instabilityPMID 26842758Read ↗

Human topoisomerases and their roles in genome stability and organizationSemantic proximity Read ↗

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomesSemantic proximity Read ↗

Topoisomerase I in Human Disease Pathogenesis and TreatmentsSemantic proximity Read ↗

DNA Topoisomerase I differentially modulates R-loops across the human genomeSemantic proximity Read ↗

Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic AnalysesSemantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.Semantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

Genome Instability Induced by Topoisomerase Misfunction.Semantic proximity Read ↗

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombinationSemantic proximity Read ↗

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor toleranceSemantic proximity Read ↗

Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha (TOP2A) in Human Malignances: A Pan-Cancer AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.