Article

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity

2024-01-23

Abstract excerpt

<h4>SUMMARY</h4> Human type-II topoisomerases, TOP2A and TOP2B, remove transcription associated DNA supercoiling, thereby affecting gene-expression programs, and have recently been associated with 3D genome architecture. Here, we study the regulatory roles of TOP2 paralogs in response to estrogen, which triggers an acute transcriptional induction that involves rewiring of genome organization. We find that, wherea...

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Literature Corpus work: 74c08bd5-8bba-5476-bbaa-cd7a00da6fc3
DOI: 10.1101/2024.01.22.576640

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