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Article

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Sperling Adam S, Jeong Kyeong Soo, Kitada Tasuku, Grunstein Michael

Abstract excerpt

DNA topoisomerases are believed to promote transcription by removing excessive DNA supercoils produced during elongation. However, it is unclear how topoisomerases in eukaryotes are recruited and function in the transcription pathway in the context of nucleosomes. To address this problem we present high-resolution genome-wide maps of one of the major eukaryotic topoisomerases, Topoisomerase II (Top2) and...

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Identifiers

PMID: 21771901
DOI: 10.1073/pnas.1106834108
PMCID: PMC3150916

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