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Human topoisomerases and their roles in genome stability and organization

28 Feb 2022

Abstract excerpt

Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) topoisomerases. In this Review, we discuss their biochemistry and their roles in transcription, DNA replication and chromatin remodelling, and highlight the recent progress made in understanding TOP3A and TOP3B. Because of recent advances in...

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PMID: 35228717
DOI: 10.1038/s41580-022-00452-3

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