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A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

24 Oct 2019

Abstract excerpt

DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability. Here, to understand the genomic distribution and mechanisms underpinning topoisomerase-induced DNA breaks, we map Top2 DNA cleavage with strand-specific nucleotide resolution across the S. cerevisiae and human...

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PMID: 31649282
DOI: 10.1038/s41467-019-12802-5

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