Article

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes

2024-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Type-II topoisomerases resolve topological stress in DNA through controlled double-strand breaks. While TOP2A is a chemotherapy target in proliferating cells, the ubiquitously expressed TOP2B is a potential off-target. Here we explore roles of TOP2B in mutagenesis by generating DNA-binding maps of TOP2B, CTCF, and RAD21 in human cancer samples and analysing these maps for driver mutations and mu...

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Literature Corpus work: 551721e1-caf4-5144-8acd-1c740b0e33b5
DOI: 10.1101/2024.11.06.622320

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